Renatrel | Norgestrel | 0.75mg | ePharma
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Renatrel

Generic: Norgestrel

Type: Tablet

Pack Size: 1s pack

Renatrel, particularly its active stereoisomer levonorgestrel, operates by binding to progesterone and estrogen receptors located in various parts of the female reproductive system, including the reproductive tract, mammary gland, hypothalamus, and pituitary gland. Upon binding to these receptors, progestins like levonorgestrel decrease the frequency of gonadotropin-releasing hormone (GnRH) release from the hypothalamus and dampen the pre-ovulatory surge of luteinizing hormone (LH). The suppression of the LH surge effectively inhibits ovulation, thereby preventing pregnancy.


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Discount Price: ৳ 39.06
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✅ Description:

Renatrel (and more specifically the active stereoisomer levonorgestrel) binds to the progesterone and estrogen receptors within the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin-releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. Loss of the LH surge inhibits ovulation and thereby prevents pregnancy.

Safety Advices


Alcohol
UNSAFE

It's recommended to avoid consuming alcohol while taking Renatrel to prevent potential adverse effects or interactions.


Pregnancy
CONSULT YOUR DOCTOR

Renatrel is considered unsafe during pregnancy


Breastfeeding

Caution should be exercised during breastfeeding. It's advisable to consult a doctor before using this medication in such situations.


Driving
CAUTION

Renatrel is unlikely to affect the ability to drive or operate machinery when prescribed. However, individual responses may vary, so it's essential to follow medical advice.


Kidney

There is insufficient information available regarding the use of Renatrel in patients with kidney dysfunction. Consulting a doctor is recommended in such cases to assess the suitability and safety of the medication.


Liver
CONSULT YOUR DOCTOR

There is insufficient information available regarding the use of Renatrel in patients with liver or kidney dysfunction. 

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✔️ Uses of Renatrel
  • Contraception
  • Menorrhagia
  • Menopausal HRT
✔️ How does Renatrel work?

Norgestrel is a progestin (female hormones). It works to prevent pregnancy by temporarily stopping the release of an egg from the ovary, or preventing fertilization (union) of the egg by sperm. It may also alter the lining of the uterus (womb) to stop a fertilized egg from attaching to the uterus.

✔️ Side Effects of Renatrel

Edema, Weakness, Anorexia, Amenorrhea, Breakthrough bleeding, Change in menstrual flow, Spotting

✔️ Quick Tips:
  • It's advised to keep your weight within a healthy range (BMI 19.5-24.9) through proper diet and regular exercise. Opt for a diet rich in whole grains, fruits, vegetables, and low-fat dairy products. Avoid smoking and limit alcohol consumption to reduce the risk of complications.
  • Regular exercise is recommended to help maintain weight and overall health, especially considering potential weight fluctuations caused by Renatrel.
  • It's essential to monitor blood pressure regularly, particularly if there are fluctuations. Any significant changes should be reported to your doctor promptly.
  • Including heart-healthy omega-3 fatty acids in your diet and using low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil may help lower elevated blood pressure. However, it's advised to consult with a healthcare professional for personalized dietary recommendations.
✔️ Indication of Renatrel

Renatrel, when combined with ethinyl estradiol, is primarily utilized for preventing pregnancy in women who choose this method of contraception. Additionally, Renatrel is employed in the treatment of various conditions, including:

  1. Abnormal Uterine Bleeding
  2. Endometriosis
  3. Hypermenorrhea
  4. Menstrual Distress (Dysmenorrhea)
  5. Polycystic Ovarian Syndrome
  6. Emergency Contraception
  7. Oral Contraceptives
✔️ Pharmacology

Progestin-only oral contraceptives, like Norgestrel tablets, work by several mechanisms to prevent conception:

Suppression of ovulation: Progestins inhibit the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus, which in turn decreases the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. This suppression of LH and FSH prevents the maturation and release of an egg from the ovary, thus inhibiting ovulation.

Thickening of cervical mucus: Progestins thicken the cervical mucus, making it more difficult for sperm to penetrate into the uterus and reach the egg for fertilization.

Alteration of the endometrium: Progestins alter the lining of the uterus (endometrium), making it less favorable for implantation of a fertilized egg.

Lowering midcycle LH and FSH peaks: By reducing the levels of LH and FSH, progestins help to maintain a state of hormonal suppression, further inhibiting ovulation and pregnancy.

Slowing movement of the ovum: Progestins slow down the movement of the egg through the fallopian tubes, reducing the likelihood of fertilization by sperm.

After oral administration, serum levels of progestins peak about two hours later, followed by rapid distribution and elimination from the body. Within 24 hours after ingestion, serum levels return to near baseline, highlighting the importance of strict adherence to the dosing schedule for efficacy.

✔️ Dosage & Administration of Renatrel

Contraception Monotherapy:

  • Adult: 30 or 37.5 mcg/day.

Monophasic Combined Oral Contraceptive (COC):

  • Adult: 150-250 mcg/day.

Triphasic COC:

  • Adult: 50-125 mcg/day.

Emergency Contraception:

  • 1.5 mg within 72 hours of coitus, or
  • 750 mcg immediately or within 72 hours of coitus, followed by a second dose of 750 mcg 12 hours later.

Menopausal Hormone Replacement Therapy (HRT) as a progestogenic component:

  • Adult: 75-250 mcg/day for 10-12 days of a 28-day cycle.
✔️ Interaction

Food Interaction:

  • Avoid grapefruit products and St. John's Wort
  • Take Renatrel at the same time every day
  • Grapefruit juice may increase plasma concentrations of drugs metabolized by CYP450 3A4

Alcohol Interaction:

  • Ethanol levels and central nervous system effects may be increased, although data are lacking

Cholesterol Interaction:

  • Some progestogenic agents may elevate plasma LDL levels, requiring closer monitoring in patients with preexisting hyperlipidemia

Hypertension Interaction:

  • Estrogens and progestogens may cause fluid retention, requiring cautious use in patients with preexisting fluid-related conditions

Unknown Drug Interactions:

  • Aripiprazole, chlorpheniramine, amoxicillin/clavulanate, citalopram, ciprofloxacin, venlafaxine, etc.

Disease Interactions:

  • Major: Hepatic neoplasms, breast malignancy, thromboembolism
  • Moderate: Depression, fluid retention, glucose intolerance, hyperlipidemia
  • Minor: Weight gain
✔️ Contraindications
  • Documented hypersensitivity
  • Active or history of breast cancer
  • Arterial thromboembolic disease, thrombophlebitis, deep vein thrombosis/pulmonary embolism, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding
  • Uncontrolled hypertension
  • Diabetes mellitus with vascular involvement
  • Jaundice with prior oral contraceptive use
  • Pregnancy or use as a diagnostic test for pregnancy
✔️ Pregnancy & Lactation

Contraindicated in pregnancy (Category X) and considered unsafe during lactation

✔️ Precautions & Warnings
  • Documented hypersensitivity
  • History of breast cancer
  • Thrombophlebitis, deep vein thrombosis/pulmonary embolism, thrombogenic valvular disease
  • Estrogen-dependent neoplasia
  • Liver disease, liver tumors
  • Undiagnosed abnormal vaginal bleeding
  • Uncontrolled hypertension
  • Diabetes mellitus with vascular involvement
  • History of migraine with aura
  • Pregnancy, smoking more than 15 cigarettes per day, and over 35 years of age
  • Serum levels should be near baseline 24 hours after ingestion, so adherence to the dosing schedule is crucial
  • Conditions such as diabetes mellitus, asthma, cardiac dysfunction, irregular menstrual bleeding patterns, bone mineral density changes, depression, epilepsy, migraine, and renal dysfunction may require monitoring
✔️ Storage Conditions:

Store in a cool and dry place.

Frequently Asked Questions (FAQ)

Renatrel prevents pregnancy by inhibiting egg release, thickening cervical fluid to hinder sperm movement, and preventing uterine wall thickening necessary for egg implantation.

Common side effects include vaginal bleeding, headaches, nausea, depression, and breast pain. If symptoms persist, consult a doctor.

No, it doesn't protect against sexually transmitted diseases. Use additional contraception methods to prevent transmission.

Generally, it's not recommended for women over 35. Consult your doctor, who will assess the benefits and risks before prescribing.

Yes, it may cause spotting between periods, which usually resolves. Inform your doctor if spotting persists.

Yes, weight gain is a known side effect. Regular exercise and a balanced diet may help manage weight.
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Check our pricing section for Renatrel price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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